abstract：OBJECTIVES:According to the 2007 National Research Council report Toxicology for the Twenty-First Century, modern methods (e.g., "omics," in vitro assays, high-throughput testing, computational methods) will lead to the emergence of a new approach to toxicology. The Salmonella mammalian microsome mutagenicity assay has...

journal_title：Environmental health perspectives

authors： Claxton LD,Umbuzeiro Gde A,DeMarini DM

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVES:There are some common occupational agents and exposure circumstances for which evidence of carcinogenicity is substantial but not yet conclusive for humans. Our objectives were to identify research gaps and needs for 20 agents prioritized for review based on evidence of widespread human exposures and potenti...

journal_title：Environmental health perspectives

authors： Ward EM,Schulte PA,Straif K,Hopf NB,Caldwell JC,Carreón T,DeMarini DM,Fowler BA,Goldstein BD,Hemminki K,Hines CJ,Pursiainen KH,Kuempel E,Lewtas J,Lunn RM,Lynge E,McElvenny DM,Muhle H,Nakajima T,Robertson LW,Rothma

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Extreme heat events (EHEs) are increasing in frequency in large U.S. cities and are responsible for a greater annual number of climate-related fatalities, on average, than any other form of extreme weather. In addition, low-density, sprawling patterns of urban development have been associated with enhanced s...

journal_title：Environmental health perspectives

authors： Stone B,Hess JJ,Frumkin H

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Cumulative lead exposure is associated with a widened pulse pressure (PP; the -difference between systolic and diastolic blood pressure), a marker of arterial stiffness and a predictor of cardiovascular disease. Polymorphisms in the hemochromatosis gene (HFE) have been shown to modify the impact of cumulativ...

journal_title：Environmental health perspectives

authors： Zhang A,Park SK,Wright RO,Weisskopf MG,Mukherjee B,Nie H,Sparrow D,Hu H

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Microcystin-LR, a cyclic heptapeptide, possesses the ability to inhibit the serine/threonine protein phosphatases PP1 and PP2A and, consequently, exhibits acute hepatocytotoxicity. Moreover, microcystin-LR induces cellular proliferation, resulting in tumor-promoting activity in hepatocytes. However, mechanis...

journal_title：Environmental health perspectives

authors： Takumi S,Komatsu M,Furukawa T,Ikeda R,Sumizawa T,Akenaga H,Maeda Y,Aoyama K,Arizono K,Ando S,Takeuchi T

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:We reviewed epidemiologic evidence related to occupational pesticide exposures and cancer incidence in the Agricultural Health Study (AHS) cohort. DATA SOURCES:Studies were identified from the AHS publication list available at http://aghealth.nci.nih.gov as well as through a Medline/PubMed database search in...

journal_title：Environmental health perspectives

authors： Weichenthal S,Moase C,Chan P

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Although from a societal point of view a modal shift from car to bicycle may have beneficial health effects due to decreased air pollution emissions, decreased greenhouse gas emissions, and increased levels of physical activity, shifts in individual adverse health effects such as higher exposure to air pollu...

journal_title：Environmental health perspectives

authors： Johan de Hartog J,Boogaard H,Nijland H,Hoek G

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:The presence of pharmaceuticals in aquatic environments and in drinking water has prompted significant public interest regarding potential adverse ecological effects and risks to human health. OBJECTIVES:The Environmental Health Summit held in North Carolina, 10-11 November 2008, explored the issues associa...

journal_title：Environmental health perspectives

authors： Rodriguez-Mozaz S,Weinberg HS

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC), or liver cancer, is the third leading cause of cancer deaths worldwide, with prevalence 16-32 times higher in developing countries than in developed countries. Aflatoxin, a contaminant produced by the fungi Aspergillus flavus and Aspergillus parasiticus in maize and nuts, is a...

journal_title：Environmental health perspectives

authors： Liu Y,Wu F

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:"Airwave" is the new communication system currently being rolled out across the United Kingdom for the police and emergency services, based on the Terrestrial Trunked Radio Telecommunications System (TETRA). Some police officers have complained about skin rashes, nausea, headaches, and depression as a conseq...

journal_title：Environmental health perspectives

authors： Wallace D,Eltiti S,Ridgewell A,Garner K,Russo R,Sepulveda F,Walker S,Quinlan T,Dudley S,Maung S,Deeble R,Fox E

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Tetraethyl lead was phased out of gasoline in Uganda in 2005. Recent mitigation of an important source of lead exposure suggests examination and re-evaluation of the prevalence of childhood lead poisoning in this country. Ongoing concerns persist about exposure from the Kiteezi landfill in Kampala, the count...

journal_title：Environmental health perspectives

authors： Graber LK,Asher D,Anandaraja N,Bopp RF,Merrill K,Cullen MR,Luboga S,Trasande L

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Benzene is a common industrial chemical known to induce leukemia and other blood disorders, as well as aneuploidy, in both human blood cells and sperm at exposures > 10 ppm. Recent reports have identified health effects at exposure levels < 1 ppm, the permissible exposure limit (PEL; 8 hr) set by the U.S. Oc...

journal_title：Environmental health perspectives

authors： Xing C,Marchetti F,Li G,Weldon RH,Kurtovich E,Young S,Schmid TE,Zhang L,Rappaport S,Waidyanatha S,Wyrobek AJ,Eskenazi B

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Although accumulating evidence suggests that exposure to organochlorine pesticides and polychlorinated biphenyls (PCBs) may contribute to the development of prostate cancer, few investigations have used biological samples to classify exposure to specific organochlorines. To our knowledge, this is the first p...

journal_title：Environmental health perspectives

authors： Sawada N,Iwasaki M,Inoue M,Itoh H,Sasazuki S,Yamaji T,Shimazu T,Tsugane S,Japan Public Health Center Based Prospective (JPHC) Study Group.

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Adverse cardiorespiratory health is associated with exposure to ambient particulate matter (PM). The highest PM concentrations in London occur in proximity to waste transfer stations (WTS), sites that experience high numbers of dust-laden, heavy-duty diesel vehicles transporting industrial and household wast...

journal_title：Environmental health perspectives

authors： Godri KJ,Duggan ST,Fuller GW,Baker T,Green D,Kelly FJ,Mudway IS

更新日期：2010-04-01 00:00:00

abstract：:Inhaled asbestos fibers may contribute to three-fourths of malignant mesotheliomas diagnosed in men and almost 40% of cases diagnosed in women. Bans on the manufacture and sale of amphibole asbestos fibers are expected to reduce the incidence of mesothelioma, but the long latency period from initial exposure to clinic...

journal_title：Environmental health perspectives

authors： Tse LA,Yu IT,Goggins W,Clements M,Wang XR,Au JS,Yu KS

更新日期：2010-03-01 00:00:00

abstract：INTRODUCTION:Ambient particulate pollution and traffic have been linked to myocardial infarction and cardiac death risk. Possible mechanisms include autonomic cardiac dysfunction. METHODS:In a repeated-measures study of 46 patients 43-75 years of age, we investigated associations of central-site ambient particulate po...

journal_title：Environmental health perspectives

authors： Zanobetti A,Gold DR,Stone PH,Suh HH,Schwartz J,Coull BA,Speizer FE

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Humans have been exposed to fine and ultrafine particles throughout their history. Since the Industrial Revolution, sources, doses, and types of nanoparticles have changed dramatically. In the last decade, the rapidly developing field of nanotechnology has led to an increase of engineered nanoparticles with ...

journal_title：Environmental health perspectives

authors： Wick P,Malek A,Manser P,Meili D,Maeder-Althaus X,Diener L,Diener PA,Zisch A,Krug HF,von Mandach U

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Eliminating silicosis is a priority of the International Labour Organization and the World Health Organization. Prevalence is particularly high in developing countries. OBJECTIVES:We describe trends in silicosis among South African gold miners who had had an autopsy between 1975 and 2007 and quantify the co...

journal_title：Environmental health perspectives

authors： Nelson G,Girdler-Brown B,Ndlovu N,Murray J

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Drinking water in multiple water districts in the Mid-Ohio Valley has been contaminated with perfluorooctanoic acid (PFOA), which was released by a nearby DuPont chemical plant. Two highly contaminated water districts began granular activated carbon filtration in 2007. OBJECTIVES:To determine the rate of de...

journal_title：Environmental health perspectives

authors： Bartell SM,Calafat AM,Lyu C,Kato K,Ryan PB,Steenland K

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Organophosphorus pesticides (OPs) are developmental neurotoxicants but also produce lasting effects on metabolism. OBJECTIVES/METHODS:We administered diazinon (DZN) or parathion (PRT) to rats on postnatal days 14 at doses straddling the threshold for systemic signs of exposure and assessed the effects on he...

journal_title：Environmental health perspectives

authors： Adigun AA,Wrench N,Seidler FJ,Slotkin TA

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:National disparities in asbestos use will likely lead to an unequal burden of asbestos diseases. OBJECTIVES:As economic status may be linked to asbestos use, we assessed, globally, the relationship between indicators of national economic development and asbestos use. METHODS:For the 135 countries that have...

journal_title：Environmental health perspectives

authors： Le GV,Takahashi K,Karjalainen A,Delgermaa V,Hoshuyama T,Miyamura Y,Furuya S,Higashi T,Pan G,Wagner G

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Humans living near industrial point emissions can experience high levels of exposures to air pollutants. Map Ta Phut Industrial Estate in Thailand is the location of the largest steel, oil refinery, and petrochemical factory complexes in Southeast Asia. Air pollution is an important source of oxidative stres...

journal_title：Environmental health perspectives

authors： Peluso M,Srivatanakul P,Munnia A,Jedpiyawongse A,Ceppi M,Sangrajrang S,Piro S,Boffetta P

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Recent policies attempting to reduce adverse effects of methylmercury exposure from fish consumption in the United States have targeted reductions in anthropogenic emissions from U.S. sources. OBJECTIVES:To analyze the prospects for future North American and international emissions controls, we assessed the...

journal_title：Environmental health perspectives

authors： Selin NE,Sunderland EM,Knightes CD,Mason RP

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:After several decades of commercial use, the flame-retardant chemicals polybrominated diphenyl ethers (PBDEs) and their metabolites are pervasive environmental contaminants and are detected in the human body. Decabrominated diphenyl ether (decaBDE) is currently the only PBDE in production in the United State...

journal_title：Environmental health perspectives

authors： Rice DC,Thompson WD,Reeve EA,Onos KD,Assadollahzadeh M,Markowski VP

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Urbanization has been correlated with hypertension (HTN) in developing countries undergoing rapid economic and environmental transitions. OBJECTIVES:We examined the relationships among living environment (urban, suburban, and rural), day/night land surface temperatures (LST), and blood pressure in selected ...

journal_title：Environmental health perspectives

authors： Estes MG Jr,Al-Hamdan MZ,Crosson W,Estes SM,Quattrochi D,Kent S,McClure LA

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Particulate matter (PM) air pollution has been associated with cardiovascular morbidity and mortality, and elevated blood pressure (BP) is a known risk factor for cardiovascular disease. A small number of studies have investigated the relationship between PM and BP and found mixed results. Evidence suggests ...

journal_title：Environmental health perspectives

authors： Mordukhovich I,Wilker E,Suh H,Wright R,Sparrow D,Vokonas PS,Schwartz J

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:The relationship of fine particulate matter < 2.5 microm in diameter (PM(2.5)) air pollution with mortality and cardiovascular disease is well established, with more recent long-term studies reporting larger effect sizes than earlier long-term studies. Some studies have suggested the coarse fraction, particl...

journal_title：Environmental health perspectives

authors： Puett RC,Hart JE,Yanosky JD,Paciorek C,Schwartz J,Suh H,Speizer FE,Laden F

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Rates of preterm birth have been rising over the past several decades. Factors contributing to this trend remain largely unclear, and exposure to environmental contaminants may play a role. OBJECTIVE:We investigated the relationship between phthalate exposure and preterm birth. METHODS:Within a large Mexic...

journal_title：Environmental health perspectives

authors： Meeker JD,Hu H,Cantonwine DE,Lamadrid-Figueroa H,Calafat AM,Ettinger AS,Hernandez-Avila M,Loch-Caruso R,Téllez-Rojo MM

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Exposure of the U.S. population to polybrominated diphenyl ethers (PBDEs) is thought to be via exposure to dust and diet. However, little work has been done to empirically link body burdens of these compounds to either route of exposure. OBJECTIVES:The primary goal of this research was to evaluate the dieta...

journal_title：Environmental health perspectives

authors： Fraser AJ,Webster TF,McClean MD

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Cigarette smoke exposure in utero and during early postnatal development increases the incidence of asthma and airway hyperresponsiveness (AHR) later in life, suggesting that a possible critical period of developmental sensitivity exists in the prenatal and early postnatal periods. OBJECTIVE:We investigated...

journal_title：Environmental health perspectives

authors： Wu ZX,Hunter DD,Kish VL,Benders KM,Batchelor TP,Dey RD

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Evidence suggests that cardiovascular effects of air pollution are mediated by inflammation and that air pollution can induce genetic expression of the interleukin-6 gene (IL6). OBJECTIVES:We investigated whether IL6 and fibrinogen gene variants can affect plasma IL-6 responses to air pollution in patients ...

journal_title：Environmental health perspectives

authors： Ljungman P,Bellander T,Schneider A,Breitner S,Forastiere F,Hampel R,Illig T,Jacquemin B,Katsouyanni K,von Klot S,Koenig W,Lanki T,Nyberg F,Pekkanen J,Pistelli R,Pitsavos C,Rosenqvist M,Sunyer J,Peters A

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Human controlled-exposure studies have assessed the impact of ambient fine particulate matter on cardiac autonomic function measured by heart rate variability (HRV), but whether these effects are modified by concomitant ozone exposure remains unknown. OBJECTIVE:In this study we assessed the impact of O(3) a...

journal_title：Environmental health perspectives

authors： Fakhri AA,Ilic LM,Wellenius GA,Urch B,Silverman F,Gold DR,Mittleman MA

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Cockroaches and mice, which are common in urban homes, are sources of allergens capable of triggering asthma symptoms. Traditional pest control involves the use of scheduled applications of pesticides by professionals as well as pesticide use by residents. In contrast, integrated pest management (IPM) involv...

journal_title：Environmental health perspectives

authors： Kass D,McKelvey W,Carlton E,Hernandez M,Chew G,Nagle S,Garfinkel R,Clarke B,Tiven J,Espino C,Evans D

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:The upward trend in industrial nations in the incidence of male genitourinary (GU) conditions may be attributed to increased exposure to endocrine disruptors. Polybrominated biphenyl (PBB), a brominated flame retardant, is one such suspected endocrine disruptor. OBJECTIVE:We investigated the relationship be...

journal_title：Environmental health perspectives

authors： Small CM,DeCaro JJ,Terrell ML,Dominguez C,Cameron LL,Wirth J,Marcus M

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Developmental exposure to polychlorinated biphenyls (PCBs) or methylmercury (MeHg) can result in a variety of neurotoxic effects, including long-term auditory deficits. However, little is known about the effects of combined exposure to PCBs and MeHg on auditory function. OBJECTIVE:We developmentally exposed...

journal_title：Environmental health perspectives

authors： Powers BE,Poon E,Sable HJ,Schantz SL

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) affects 71 million American adults and remains the leading cause of death in the United States and Europe. Despite studies that suggest that the development of CVD may be linked to intrauterine growth or early events in childhood, little direct experimental evidence supports the ...

journal_title：Environmental health perspectives

authors： Ng SP,Conklin DJ,Bhatnagar A,Bolanowski DD,Lyon J,Zelikoff JT

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Population-based studies have estimated health risks of short-term exposure to fine particles using mass of PM(2.5) (particulate matter

journal_title：Environmental health perspectives

authors： Peng RD,Bell ML,Geyh AS,McDermott A,Zeger SL,Samet JM,Dominici F

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Although many studies have examined the effects of air pollution on mortality, data limitations have resulted in fewer studies of both particulate matter with an aerodynamic diameter of 2.5 and < 10 mi...

journal_title：Environmental health perspectives

authors： Zanobetti A,Schwartz J

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Chronic exposure to traffic-related air pollution (TRAP) may contribute to premature mortality, but few studies to date have addressed this topic. OBJECTIVES:In this study we assessed the association between TRAP and mortality in Toronto, Ontario, Canada. METHODS:We collected nitrogen dioxide samples over ...

journal_title：Environmental health perspectives

authors： Jerrett M,Finkelstein MM,Brook JR,Arain MA,Kanaroglou P,Stieb DM,Gilbert NL,Verma D,Finkelstein N,Chapman KR,Sears MR

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:C60 fullerenes and single-walled carbon nanotubes (SWCNT) are projected to be used in medicine and consumer products with potential human exposure. The hazardous effects of these particles are expected to involve oxidative stress with generation of oxidatively damaged DNA that might be the initiating event i...

journal_title：Environmental health perspectives

authors： Folkmann JK,Risom L,Jacobsen NR,Wallin H,Loft S,Møller P

更新日期：2009-05-01 00:00:00